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Assess patient for signs and symptoms of anaphylaxis (rash oral antibiotics for acne minocycline buy generic minocin online, pruritus, laryngeal edema, wheezing) for at least 30 min following injection. Keep epinephrine and resuscitation equipment close by in the event of an anaphylactic reaction. Lab Test Considerations: Monitor hemoglobin, hematocrit, and reticulocyte values prior to and every 3 wk during the first 2 mo of therapy and periodically thereafter. Serum ferritin and iron levels may also be monitored to assess effectiveness of therapy. Iron Dextran: Monitor hemoglobin, hematocrit, reticulocyte values, transferrin, ferritin, total ironbinding capacity, and plasma iron concentrations periodically during therapy. Iron Sucrose: Monitor hemoglobin, hematocrit, serum ferritin, and transferritin saturation prior to and periodically during therapy. Toxicity and Overdose: Early symptoms of overdose include stomach pain, fever, nausea, vomiting (may contain blood), and diarrhea. Late symptoms include bluish lips, fingernails, and palms; drowsiness; weakness; tachycardia; seizures; metabolic acidosis; hepatic injury; and cardiovascular collapse. Late complications of overdose include intestinal obstruction, pyloric stenosis, and gastric scarring. If patient is comatose or seizing, gastric lavage with sodium bicarbonate is performed. Additional supportive treatments to maintain fluid and electrolyte balance and correction of metabolic acidosis are also indicated. Potential Nursing Diagnoses Activity intolerance (Indications) Implementation Discontinue oral iron preparations prior to paren- teral administration. Dilute in water or fruit juice, full glass (240 mL) for adults and 1/2 glass (120 mL) for children, and administer with a straw or place drops at back of throat. Avoid using antacids, coffee, tea, dairy products, eggs, or whole-grain breads with or within 1 hr after administration of ferrous salts. If calcium supplementation is needed, calcium carbonate does not decrease absorption of iron salts if supplements are administered between meals. The remaining portion may be administered after 1 hr, if no adverse symptoms have occurred. Change needles between withdrawal from container and injection to minimize staining of subcut tissues.

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Apply a small amount of mupirocin to the affected area 3 times daily and rub in gently antibiotic resistance oxford generic 50 mg minocin overnight delivery. Nasal: Apply one half of the ointment from the single-use tube to each nostril twice daily (morning and evening) for 5 days. After application, close nostrils by pressing together and releasing sides of the nose repeatedly for 1 min. Patient/Family Teaching Instruct patient on the correct application of mupi- Resolution of lesions. Advise patient to apply medication exactly as directed for the full course of therapy. Topical: Teach patient and family appropriate hygienic measures to prevent spread of impetigo. Instruct parents to notify school nurse for screening and prevention of transmission. If no clinical response is Interactions Drug-Drug: Nasal mupirocin should not be used concurrently with other nasal products. Drug-Natural Products: Concomitant use with astragalus, echinacea, and melatonin may interfere with immunosuppression. Action A purified immunoglobulin antibody that acts as an immunosuppressant by interfering with normal T-cell function. Notify health care professional if patient has experienced 3% or more weight gain in the previous week. Instruct patient to continue to avoid crowds and persons with known infections, as this drug also suppresses the immune system. Advise patient to notify health care professional at first sign of rash, urticaria, tachycardia, dyspnea, or difficulty swallowing. Caution patient to avoid driving or other activities requiring alertness until response is known. Instruct patient not to receive any vaccinations and to avoid contact with persons receiving oral polio vaccine without advice of health care professional. Initial dose is administered during hospitalization; patient should be monitored closely for 48 hr. Mycophenolic acid: Prevention of rejection in allogenic renal transplantation (used concurrently with cyclosporine and corticosteroids).

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Effects may be pby antifibrinolytic agents antibiotic resistance virulence buy discount minocin 50 mg on line, including aminocaproic acid or tranexamic acid. Drug-Natural Products:qanticoagulant effect and bleeding risk with anise, arnica, chamomile, clove, dong quai, fenugreek, feverfew, garlic, ginger, ginkgo, Panax ginseng, licorice, and others. Exercise Extreme Caution in: Patients receiving concurrent anticoagulant therapy (qrisk of intracranial bleeding). Streptokinase may be less effective if administered between 5 days and 6 mo of a streptococcal infection. Altered sensorium or neurologic changes may be indicative of intracranial bleeding. Deep Vein Thrombosis/Acute Arterial Thrombosis: Observe extremities and palpate pulses of affected extremities every hour. Computerized tomography, impedance plethysmography, quantitative Doppler effect determination, and/or angiography or venography may be used to determine restoration of blood flow and duration of therapy; however, repeated venograms are not recommended. Cannula/Catheter Occlusion: Monitor ability to aspirate blood as indicator of patency. Bleeding time may be assessed before therapy if patient has received platelet inhibitors. Obtain type and crossmatch and have blood available at all times in case of hemorrhage. Stools should be tested for occult blood loss and urine for hematuria periodically during therapy. Streptokinase Powder for injection: 250,000 units/vial, 750,000 units/vial, 1,500,000 units/vial. Monitor vital signs, including temperature, continu- ously for coronary thrombosis and at least every 4 hr during therapy for other indications. Internal bleeding may also occur (decreased neurologic status; abdominal pain with coffee-grounds emesis or black, tarry stools; hematuria; joint pain). If uncontrolled bleeding occurs, stop medication and notify health care professional immediately. Assess patient for hypersensitivity reaction (rash, dyspnea, fever, changes in facial color, swelling around the eyes, wheezing).

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The affection of the ovary from tubal infection occurs by the following routes: Directly from the exudates contaminating the ovarian surface producing perioophoritis antimicrobial guidelines 2012 order minocin 50 mg line. Through lymphatics of the mesosalpinx and mesovarium producing interstitial oophoritis. If the organisms are severe, an abscess is formed and a tubo-ovarian abscess results. Direct affection of the ovaries without tubal involvement may be due to mumps or influenza. This is because the capsule of the ovary is elastic and as such, ischemic injury to the graafian follicles is not likely. Even if some follicles are damaged, many are left behind to carry on the reproductive function. Intravenous fluids to correct dehydration and nasogastric suction in the presence of abdominal distension or ileus are maintained. There is an indurated tender mass usually unilateral, which extends to the lateral pelvic wall and to which the uterus is firmly fixed. Rectal examination confirms the indurated tender mass or horse shoe-shaped induration of the uterosacral ligaments surrounding the rectum. An abscess formation is featured by spiky rise of temperature, toxic look, and fluctuant swelling in the regions mentioned earlier. Chronic the clinical features vary, as it is often associated with chronic salpingo-oophoritis and as such, the symptoms and signs are overshadowed by the latter condition. The chief complaint is chronic deep seated pelvic pain, may be localized to one side. There is intense hyperemia with exudation of serous fluid, lymph, and polymorphonuclear leukocytes. The purulent exudate may be localized or may have extrapelvic extension along the tract of blood vessels and ureter. The abscess thus points towards the perinephric region along the ureter, to the buttock along the gluteal vessels, to the thigh along the external iliac vessels and to the groin above the inguinal ligament. Rarely, the abscess may burst into the pelvic organs, or into the peritoneal cavity. On the other hand multiseptated cystic mass with multiple internal echoes are seen. Pain lower abdomen-variable degrees Urinary symptoms-difficulty or even retention of urine. Per abdomen Tenderness and rigidity in lower abdomen A mass may be felt in the suprapubic region - tender, irregular, soft, and resonant on percussion. Only when an abscess is pointing and easily accessible that it should be drained surgically.

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Discontinue tolcapone if liver function tests reach two times the upper limit of normal or if jaundice occurs; do not reinstate antibiotics for uti urinary tract infection generic minocin 50 mg without a prescription. Pharmacokinetics Absorption: Rapidly absorbed following oral administration with 65% bioavailability. Contraindications/Precautions Contraindicated in: Hypersensitivity; Concurrent Patient/Family Teaching Instruct patient to take medication as directed. Mayqthe effects of methyldopa, apomorphine, dobutamine, or isoproterenol; dose reduction may be necessary. Abrupt discontinuation or rapid dose reduction may result in neuroleptic malignant syndrome (qtemperature, muscular rigidity, altered consciousness). Caution patient to make position changes slowly to minimize orthostatic hypotension, especially at the beginning of therapy. Inform patient and caregiver that hallucinations, nausea, dyskinesia, or dystonia may occur during tolcapone therapy. Instruct patient to notify health care professional if persistent diarrhea occurs. Advise patient to notify health care professional if symptoms of liver failure (clay-colored stools, jaundice, fatigue, loss of appetite, lethargy), suspicious or unusual skin changes, hallucinations, or new or increased gambling, sexual, or other intense urges occur. Monitor for signs and symptoms of liver dysfunction (persistent nausea, fatigue, lethargy, anorexia, jaundice, dark urine, pruritus, right upper quadrant tenderness) periodically during therapy. Interactions Drug-Drug: Erythromycin, clarithromycin, ketoconazole, itraconazole, and miconazole may inhibit metabolism andqeffects. Action Acts as a competitive muscarinic receptor antagonist resulting in inhibition of cholinergically mediated bladder contraction. Extended-release capsules should be swallowed or fesoterodine; Urinary retention; Gastric retention; Uncontrolled angle-closure glaucoma; Lactation: Lactation. Contraindications/Precautions Contraindicated in: Hypersensitivty to tolterodine whole; do not open, crush, dissolve, or chew. Caution pa- tient to avoid driving or other activities requiring alertness until response to medication is known. Instruct patient to notify health care professional immediately if rash or signs and symptoms of anaphylaxis or angioedema occur. Evaluation/Desired Outcomes Decreased urinary frequency, urgency, and urge in- continence. Action cin, itraconazole, telithromycin, saquinavir, nelfinavir, ritonavir, and nefazodoneqlevels and may qeffects and risk of toxicity; concurrent use should be avoided. Levels and risk of toxicity are alsoqP-gp inhibitors including cyclosporine; dosage adjustments may be necessary. Drug-Food: Grapefruit juiceqlevels and the risk of toxicity; avoid concurrent use. Acts as a selective vasopressin V2-receptor antagonist, resulting in increased renal water excretion and increased serum sodium.

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Assess patient for signs of pancreatitis (nausea antimicrobial phone case 50 mg minocin buy visa, vomiting, abdominal pain, increased serum lipase or amylase) periodically during therapy. Monitor triglyceride and cholesterol levels prior to initiating therapy and periodically during therapy. Monitor liver function before and during therapy, especially in patients with underlying hepatic disease, including hepatitis B and hepatitis C, or marked transaminase elevations. Solution is stable if refrigerated until expiration date on label or 2 mo at room temperature. If oral solution is used in babies younger than 14 days, monitor for increases in serum osmolality, serum creatinine, and other signs of toxicity. Patient/Family Teaching Emphasize the importance of taking lopinavir/rito- navir as directed, at evenly spaced times throughout day. Do not take more than prescribed amount, and do not stop taking this or other antiretrovirals without consulting health care professional. Advise patient to read the Patient Information prior to taking this medication and with each Rx refill in case of changes. Advise patient that the longterm effects of lopinavir/ritonavir are unknown at this time. Instruct patient to notify health care professional immediately if rash, symptoms of lactic acidosis (tiredness or weakness, unusual muscle pain, trouble breathing, stomach pain with nausea and vomiting, cold especially in arms or legs, dizziness, fast or irregular heartbeat) or if signs of hepatotoxicity (yellow skin or whites of eyes, dark urine, light-colored stools, lack of appetite for several days or longer, nausea, abdominal pain) occur. Advise patient to notify health care professional if increased thirst or hunger; unexplained weight loss; or increased urination occurs. Caution patients taking sildenafil, vardenafil, or tadalafil of increased risk of associated side effects (hy- potension, visual changes, sustained erection). Inform patient that redistribution and accumulation of body fat may occur causing central obesity, dorsocervical fat enlargement (buffalo hump), peripheral wasting, breast enlargement, and cushingoid appearance. Rep: Advise patients taking oral contraceptives to use a nonhormonal method of birth control during lopinavir/ritonavir therapy. Instruct patient to notify health care professional if pregnancy is planned or suspected and to avoid breast feeding. Therapeutic Effects: Decreased symptoms of allergic reactions (nasal stuffiness; red, swollen eyes, itching). Metabolism and Excretion: Rapidly and exten- sively metabolized during first pass through the liver. Syrup contains sodium benzoate, avoid use in neonates; Geri:qrisk of adverse reactions. For rapidly disintegrating tablets (Alavert, Clari- tin Reditabs)- place on tongue.

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Menstrual history the following features in relation to menstruation are strong evidences of ovulation treatment for uti macrobid 50 mg minocin with visa. If pregnancy occurs, the rise Chapter 17 x Infertility of temperature sustains along with absence of the period. Principle the rise of temperature is secondary to rise in progesterone output following ovulation. The primary reason for the rise is the increase in the production and secretion of norepinephrine which is also thermogenic. Procedures: the patient is instructed to take her oral temperature daily on waking up in the morning before rising out of the bed. Days when intercourse takes place should also be noted on the chart for better evaluation of coital frequency. Interpretation: the body temperature maintaining throughout the first half of the cycle is raised to 0. It also helps the couple to determine the most fertile period, if the cycle is irregular. However, it has to be maintained for longer periods during management of ovulation induction. Disappearance of fern pattern beyond 22nd day of the cycle, which was present in the midcycle is suggestive of ovulation. Following ovulation, there is loss of stretchability (spinbarkeit), which was present in the mid cycle (see p. Vaginal cytology: Maturation index shifts to the left from the midcycle to the mid second half of cycle due to the effect of progesterone (see p. However, a single smear on day 25 or 26 of the cycle reveals features of progesterone effect, if ovulation occurs. Hormone estimation Serum progesterone: Estimation of serum progesterone is done on day 8 and 21 of a cycle (28 days). An increase in value from less than 1 ng/mL to greater than 6 ng/mL suggests ovulation. Dilatation and curettage is, however reserved in cases where bulk endometrial study is required as in endometrial tuberculosis. Barrier contraceptive should be prescribed during the cycle to prevent accidental conception. Findings: Evidences of secretory activity of the endometrial glands in the second half of the cycle give not only the diagnosis of ovulation but can predict the functional integrity of the corpus luteum.

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Causes excretion of: Water broken dog's tail treatment order genuine minocin, Sodium, Potassium, Chloride, Calcium, Phosphorus, Magnesium, Urea, Uric acid. Therapeutic Effects: Mobilization of excess fluid in oliguric renal failure or edema. Decreased hemolysis when used as an irrigant after transurethral prostatic resection. Distribution: Confined to the extracellular space; does not usually cross the blood-brain barrier or eye. Assess patient for anorexia, muscle weakness, numbness, tingling, paresthesia, confusion, and excessive thirst. Increased Intracranial Pressure: Monitor neurologic status and intracranial pressure readings in patients receiving this medication to decrease cerebral edema. Increased Intraocular Pressure: Monitor for persistent or increased eye pain or decreased visual acuity. Lab Test Considerations: Renal function and serum electrolytes should be monitored routinely throughout therapy. Excess fluid volume (Indications) Risk for deficient fluid volume (Side Effects) Observe infusion site frequently for infiltration. Ex- Do not administer electrolyte-free mannitol solution travasation may cause tissue irritation and necrosis. If blood must be administered simultaneously with mannitol, add at least 20 mEq NaCl to each liter of mannitol. Confer with health care professional regarding placement of an indwelling Foley catheter (except when used to decrease intraocular pressure). Y-Site Compatibility: acetaminophen, acyclovir, alemtuzumab, alfentanil, allopurinol, amifostine, amikacin, aminocaproic acid, aminophylline, amiodarone, amphotericin B lipid complex, ampicillin, anidulafungan, argatroban, ascorbic acid, atropine, azithromycin, aztreonam, benztropine, bivalirudin, bleomycin, bumetanide, buprenorphine, butorphanol, calcium chloride, calcium gluconate, cangrelor, carboplatin, carmustine, caspofungin, cefazolin, cefotaxime, cefotetan, cefoxitin, ceftaroline, ceftazidime, ceftriaxone, cefuroxime, chloramphenicol, chlorpromazine, cisatracurium, cisplatin, cladribine, clindamycin, cyanocobalamin, cyclophosphamide, cyclosporine, cytarabine, dacarbazine, dactinomycin, daptomycin, daunorubicin hydrochloride, dexamethasone, dexmedetomidine, dexrazoxane, digoxin, diltiazem, diphenhydramine, dobutamine, docetaxel, dolasetron, dopamine, doripenem, doxorubicin hydrochloride, doxycycline, enalaprilat, ephedrine, epinephrine, epirubicin, epoetin alfa, eptifibatide, ertapenem, erythromycin, esmolol, etoposide, etoposide phosphate, famotidine, fenoldopam, fentanyl, fluconazole, fludarabine, fluorouracil, folic acid, foscarnet, fosphenytoin, furosemide, ganciclovir, gemcitabine, gentamicin, glycopyrrolate, granisetron, heparin, hetastarch, hydrocortisone, hydromorphone, idarubicin, ifosfamide, indomethacin, insulin, irinotecan, isoproterenol, ketorolac, labetalol, leucovorin, levofloxacin, lidocaine, linezolid, lorazepam, magnesium sulfate, melphalan, meperidine, mesna, methotrexate, methyldopate, methylprednisolone, metoclopramide, metoprolol, metronidazole, midazolam, milrinone, mitomycin, mitoxantrone, morphine, moxifloxacin, multivitamins, mycophenolate, nafcillin, nalbuphine, naloxone, nesiritide, nicardipine, nitroglycerin, nitroprusside, norepinephrine, octreotide, ondansetron, oxacillin, oxaliplatin, oxytocin, paclitaxel, palonosetron, pamidronate, pancuronium, papaverine, pemetrexed, penicillin G, pentamidine, pentazocine, pentobarbital, phenobarbital, phenylephrine, phytonadione, piperacillin/tazobactam, potassium acetate, potassium chloride, procainamide, prochlorperazine, promethazine, propofol, propranolol, protamine, pyridoxine, quinupristin/dalfopristin, ranitidine, remifentanil, rituximab, rocuronium, sargramostim, sodium acetate, sodium bicarbonate, streptokinase, succinylcholine, sufentanil, tacrolimus, telavancin, teniposide, theophylline, thiamine, thiotepa, tigecycline, tirofiban, tobramycin, topotecan, trastuzumab, vancomycin, vasopressin, vecuronium, verapamil, vinblastine, vincristine, vinorelbine, voriconazole, zoledronic acid. Y-Site Incompatibility: amphotericin B liposome, cefepime, dantrolene, diazepam, doxorubicin liposomal, filgrastim, imipenem/cilastatin, phenytoin, trimethoprim/sulfamethoxazole.

Xardas, 46 years: Instruct patient not to receive any vaccinations without advice of health care professional; ifosfamide may decrease antibody response to and increase risk of adverse reactions from live-virus vaccines. If doses 2000 mg/day are required, give in 3 divided doses (not to exceed 2500 mg/day) or 850 mg once daily; mayqby 850 mg at 2-wk intervals (in divided doses) up to 2550 mg/day in divided doses (up to 850 mg 3 times daily); Extended-release tablets- 500­ 1000 mg once daily with evening meal, mayqby 500 mg at weekly intervals up to 2500 mg once daily. Local advanced or metastatic nonsquamous non­ small cell lung cancer as initial therapy (with cisplatin), in previously treated patients (as monotherapy), or as maintenance treatment in patients whose disease has not progressed after 4 cycles of platinumbased chemotherapy.

Murak, 43 years: Restrict amount of tenofovir 1171 drug available to patient, especially if patient is depressed or suicidal or has a history of addiction. After starting therapy, children, adolescents, and young adults should be seen by health care professional at least weekly for 4 wk, every 3 wk for next 4 wk, and on advice of health care professional thereafter. Patient/Family Teaching Advise patient to take this medication with a full glass of water and to remain in an upright position for 15­ 30 min after administration.

Taklar, 42 years: Depresses the sensory cortex, decreases motor activity, and alters cer- depressants, including alcohol, antihistamines, opioid analgesics, and other sedative/hypnotics. Metabolism and Excretion: 59% excreted unchanged in urine; 32% excreted in urine as metabolites. Advise patient to notify health care professional prior to next dose of zolmitriptan if pain or tightness in the chest occurs during use.

Sanuyem, 32 years: Absorption: Rapidly metabolized following absorption (extensive first-pass effect). Monitor hepatic function tests, prostate specific antigen and serum cholesterol levels periodically during therapy. Simultaneous topical use of skin, scalp, or hair products mayqsystemic absorption.

Akascha, 49 years: Rep: Advise female patients to use an additional non- hormonal method of contraception during therapy and until next menstrual period. During initial infection, the fimbriae are edematous and indrawn with the serous surface, adhering together to produce closure of the abdominal ostium. The free anastomosis between the superior rectal veins of the portal, the middle and inferior rectal veins of the systemic system explains the liver metastases from the genital organs.

Corwyn, 44 years: Intraoperative antihypertensive/antiarrhythmic- 250­ 500-mcg/kg loading dose over 1 min initially, followed by 50-mcg/ kg/min infusion for 4 min; if no response within 5 min, give 2nd loading dose of 250­ 500 mcg/kg over 1 min, thenqinfusion to 100 mcg/kg/min for 4 min. In combination with: emtricitabine (Truvada); emtricitabine and rilpivirine (Complera); efavirenz and emtricitabine (Atripla); elvitegravir, cobicistat, and emtricitabine (Stribild). Patient/Family Teaching Instruct patient to take zonisamide as directed, even if feeling well.

Jose, 34 years: But the localization of pus in the pouch of Douglas is evidenced by: Symptoms Spiky rise of high temperature with chills and rigor Rectal tenesmus-frequent passage of loose mucoid stool 144 Textbook of Gynecology Health care providers are trained up to follow a standardized protocol (flowcharts) for treatment such a patient. Lab Test Considerations: May cause transientp in serum potassium concentrations with nebulization or at higher than recommended doses. Vesicovaginal septum: It is a fibroelastic connective tissue with some smooth muscle fibers.

Navaras, 64 years: Contraindications/Precautions Contraindicated in: History of stroke, transient is- rickets. May causepneutrophil counts; median time to first episode is 15 days (13­ 117 days) and median duration of Grade 3 neutropenia was 7 days. Inform patient that increased amounts of riboflavin in the diet may be required; consult health care professional.

Owen, 30 years: If dose is less effective after a few weeks, do not increase dose without consulting health care professional. Patient/Family Teaching Advise patients to start therapy with this herbal supplement only after evaluation by a health care professional who will provide continued followup care. Advise patients to contact health care professional if their symptoms do not improve after 6 wk of therapy, if their symptoms worsen, or they develop a skin infection.

Urkrass, 60 years: Contraindications/Precautions Contraindicated in: Hypersensitivity; Uncontrolled Prophylaxis of Thromboembolism Subcut (Adults): 5000 units q 8­ 12 hr (may be started 2 hr prior to surgery). Metabolism and Excretion: Rapidly converted to acyclovir via intestinal/hepatic metabolism. Half-life: Peginterferon alpha-2a- 50­ 160 hr; interferon alpha-2b- 2­ 3 hr; peginterferon alpha2b- 40 hr.

Emet, 56 years: Availability (generic available) Transdermal therapeutic system: TransdermScop- 1. The units cancel, leaving: 125 1 10 gtt 1 60 min 1 Next, multiply each level across and divide the numerator by the denominator for the answer. It supports the pelvic viscera and counteracts the downward thrust of increased intraabdominal pressure.

Fedor, 31 years: Antiemetic: Assess patient for nausea and vomiting before and after administration. Contraindications/Precautions Contraindicated in: Hypersensitivity; Concurrent Potential Nursing Diagnoses Ineffective tissue perfusion (Indications) Activity intolerance (Indications) Implementation Ranolazine should be used in combination with am- lodipine, beta blockers, or nitrates. Contraindications/Precautions Contraindicated in: Hypersensitivity; Premenopau- Evaluation/Desired Outcomes Slowing of disease progression in women with ad- vanced breast cancer.

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