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With increasing age hair loss lotion finpecia 1 mg order on-line, rotator cuff disease results in shoulder pain and limited shoulder function. The elbow is a compound synovial joint composed of a complex of two closely related articulations between the humerus and both the ulna and radius. Clinical evaluation the neck and shoulder are two of the most common sources of musculoskeletal pain. The majority of neck pain is acute and selflimiting and can be attributed to a mechanical or postural cause. Shoulder pain has a selfreported point prevalence of between 14% and 26% in the general population. Pain proximal to the shoulder, in the shoulder girdle or over the scapula indicates referred pain from the neck. This includes the scapulothoracic articulation, where the scapula slides on the ribcage. A structured examination must define the source of the pain and the degree of functional deficit and coexisting pathologies. It includes careful inspection, palpation, movement, special clinical tests and a neurological assessment. Depending on the findings, appropriate further investigations should then be undertaken. Restricted cervical movements and local tenderness help to confirm the local origin of neck pain. Chronicity is weakly predicted by the presence of concomitant low back pain, older age and previous episodes of neck pain. It usually responds to conservative treatment with analgesics and simple exercise regimes. Patients should be instructed to return for further assessment if symptoms persist or change in quality. The history must also elicit the presence of any clinical features that indicate potentially serious systemic and musculoskeletal pathology. The clinician should determine the mode of onset and duration of the pain, its nature, site, radiation, temporal characteristics, exacerbating and relieving features, and associated symptoms. However, nocturnal pain should raise suspicion of nerve root pain, bony pathology or underlying malignancy, particularly if there is a history of cancer and/or systemic symptoms. Joint swelling around the shoulder or elbow can occur in relation to arthropathy, infection or trauma.

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Plain radiographic imaging is not always helpful in the assessment of patients with knee pain hair loss labs order finpecia 1 mg with amex, and the diagnosis of osteoarthritis is often a clinical one. Anterior knee pain due to patella maltracking can occur in the degenerative knee and will respond to weight loss and knee strengthening exercise. This should always be done before more riskladen, invasive or expensive interventions. The high prevalence of knee pain in the community means that such treatments should be simple, safe, costeffective and, ideally, selfadministered. The place of oral glucosamine and similar nutraceuticals is still debated in the presence of conflicting reports from different studies, and no treatment interventions have yet been convincingly shown to alter the course of osteoarthritis. Their use should be considered only after failure of simple measures such as weight loss, exercise regimes and use of simple analgesics. Local treatments, such as topical nonsteroidal antiinflammatory gels, are effective in the short term, particularly in the setting of acute symptomatic flares. Intraarticular steroids can be very effective in relieving knee pain for several weeks or months. Arthroscopic surgical treatment for arthritis of the knee is reserved for the treatment of mechanical symptoms such as joint catching, locking or instability due to a loose body or meniscal tear. In the absence of mechanical symptoms, arthroscopic interventions are no more effective than placebo. In up to 40% of patients, disease does not progress significantly after initial presentation, or does so very slowly. In these patients use of simple, safe, costeffective treatments is essential for effective and economic management. Joint replacement surgery is indicated in those patients whose disease progresses such that their symptoms, such as pain, stiffness, loss of function or progressive deformity, become poorly controlled despite the treatment measures outlined above. The main indication for referral for joint replacement surgery is poor joint pain control and loss of function. Unicompartmental joint replacement is associated with good functional outcomes in suitable patients, but progression of arthritis in the nonreplaced parts of the knee and higher prosthesis failure rates mean that the longterm survival of these prosthesis types is lower than total knee replacement. The results of joint replacement surgery are excellent in over 90% of patients in terms of improvement in healthrelated quality of life. Knee pain in systemic disease Pain and swelling in the knee may be a feature of systemic illness. Patients should be asked about pain in other joints, previously painful, swollen joints and a family history of joint disease. Systemic symptoms such as malaise, pyrexia, anorexia and weight loss may provide clues to the origin of the knee pain. Symptoms affecting other organs, such as the skin, bowel, eyes or genitourinary tract, may also be of diagnostic relevance.

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Intravenous magnesium versus nimodipine in the treatment of patients with aneurysmal subarachnoid hemorrhage: a randomized study hair loss due to thyroid finpecia 1 mg order with mastercard. Intravenous magnesium sulfate after aneurysmal subarachnoid hemorrhage: a prospective randomized pilot study. Prophylactic magnesium for improving neurologic outcome after aneurysmal subarachnoid hemorrhage: systematic review and meta-analysis. Randomized trial of clazosentan in patients with aneurysmal subarachnoid hemorrhage undergoing endovascular coiling. Effect of prior statin use on functional outcome and delayed vasospasm after acute aneurysmal subarachnoid hemorrhage: a matched controlled cohort study. Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage. Biologic effects of Simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial. Atorvastatin decreases computed tomography and S100-assessed brain ischemia after subarachnoid aneurysmal hemorrhage: a comparative study. Effects of statins-use for patient with aneurysmal subarachnoid hemorrhage: a meta-analysis of randomized controlled trials. High-dose Simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial. Effect of normal saline bolus on cerebral blood flow in regions with low baseline flow in patients with vasospasm following subarachnoid hemorrhage. Goal-directed fluid management by bedside transpulmonary hemodynamic monitoring after subarachnoid hemorrhage. Multicenter prospective cohort study on volume management after subarachnoid hemorrhage. Hemodynamic changes according to severity of subarachnoid hemorrhage and cerebral vasospasm. Early intensive versus minimally invasive approach to postoperative hemodynamic management after subarachnoid hemorrhage. Relative importance of hypertension compared with hypervolemia for increasing cerebral oxygenation in patients with cerebral vasospasm after subarachnoid hemorrhage. Current practices of triple-H prophylaxis and therapy in patients with subarachnoid hemorrhage. Complications of SwanGanz catheterization for hemodynamic monitoring in patients with subarachnoid hemorrhage. Safety of hypertensive hypervolemic therapy with phenylephrine in the treatment of delayed ischemic deficits after subarachnoid hemorrhage. Hypertensive encephalopathy as a complication of hyperdynamic therapy for vasospasm: report of two cases.

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Macrophages also induce the production of growth factors and more cytokines by activating T cells and B cells hair loss in men propecia finpecia 1 mg purchase without prescription. Oxidative stress and free radicals in atherosclerotic walls may also activate the immune response. Several studies support the hypothesis that aneurysm formation and atherosclerosis might be related. In a histologic examination of atherosclerotic saccular aneurysms, Kosierkiewicz and coworkers46 found that aneurysm size is related to the progression of atherosclerotic plaque. In small aneurysms, atherosclerotic lesions were characterized by intimal thickening with only minimal inflammatory cell infiltration. In large aneurysms, atherosclerotic lesions were more advanced and exhibited more extensive macrophage, lymphocyte, and natural killer cell infiltration. In a study involving 50 patients with intracranial aneurysms and no significant atheromatous disease, Bolger and associates106 found that elevated serum levels of lipoprotein (a) (Lp[a]), an independent risk factor for atherosclerosis, were also detected in patients with aneurysms, whose average serum Lp(a) levels were twofold higher than those in healthy normal controls. These data suggest that Lp(a) is also associated with the presence of intracranial aneurysms. In an investigation of the wall shear stress distribution between areas with and without atherosclerotic changes in a single, large middle cerebral artery aneurysm, Tateshima and colleagues107 showed that low wall shear stress was correlated with the presence of atherosclerotic areas. Increased expression of phosphorylated c-Jun amino-terminal kinase and phosphorylated c-Jun in human cerebral aneurysms: role of the c-Jun amino-terminal kinase/c-Jun pathway in apoptosis of vascular walls. In an autopsy study of six intracranial aneurysms, Hassler38 detected slight atherosclerotic changes near the vicinity of the aneurysms. However, no apparent relationship between the presence of atherosclerosis and aneurysms was found. Although elevated Lp(a) levels were associated with intracranial aneurysm formation (described earlier), examination of Lp(a) expression in intracranial aneurysm samples and control arteries with and without atherosclerosis showed that Lp(a) expression in aneurysms may occur independently of atherosclerosis. Identifying causative genetic mutations is important for obtaining a deeper understanding of the pathogenesis of aneurysm formation and has been a focus of research since the early 2000s. From work in our laboratory, a susceptibility region in chromosome 13q was noted through the use of a genome-wide linkage approach in a single, large white family with autosomal dominant intracranial aneurysms. Squares represent male family members; circles represent female family members; black symbols represent affected persons; white symbols represent unaffected persons; gray symbols represent unknown phenotype; plus signs indicate R450X mutation carriers; and minus signs indicate noncarriers. Triangles represent predicted N-glycosylation sites; circles represent predicted phosphorylation sites. This aneurysm is termed saccular because the neck (black arrow) arises from an arterial branch point, the internal carotid artery (at the base of the aneurysm neck), and the opthalmic artery (red arrow). Red arrow indicates superior cerebellar artery; black arrow indicates the neck of the aneurysm arising from the trunk of the artery, not at its origin from the basilar artery (white arrow). Because this aneurysm arose from the trunk and not a branch point, it was classified as fusiform.

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The most common mechanism of ischemic stroke in the majority of patients is probably thromboembolism hair loss kansas city order finpecia now. Separation of the arterial wall layers is a dissection and is anatomically similar to spontaneous arterial dissection and dissection associated with trivial trauma. Blunt cerebrovascular injuries: redefining screening criteria in the era of noninvasive diagnosis. The fusiform subtype is hypothesized to result from arterial stretch and carries a more benign natural history: more than half (52. The strongest predictor of a carotid artery injury is a basilar skull fracture,11,30 and the strongest predictor of a vertebral artery injury is a cervical spine injury. Common types of injury include intimal tear (A); intimal tear with associated thrombosis (B); dissecting aneurysm formation, resulting from disruption of the internal elastic lamina and bulging of the adventia (C); and intramural hematoma (D). This sequence of events is supported by the finding that 8% of carotid artery injuries consisting only of a luminal irregularity later progress to traumatic aneurysms. These subtypes are hypothesized to result from different pathologic mechanisms and harbor important clinical distinctions. The six dots representing patients with stroke are highlighted (filled in purple). In cases of traumatic aneurysm formation, large aneurysms may cause mass effect or, on rare occasion, rupture. Doppler Ultrasonography Doppler ultrasonography has been advocated as a faster and less expensive alternative to angiography for screening of traumatically injured patients. Additional false-positive findings can result from arterial stretching over bone, foreign body artifact, and atherosclerotic plaque. For vertebral artery injuries, stroke and mortality rates appear to be independent of the pattern of injury. The most widely reported antithrombotic regimen has been anticoagulation with intravenous heparin. However, the rate of hemorrhagic complication is relatively high,10,11,43,58 and a significant proportion of traumatically injured patients have comorbid conditions that preclude this type of therapy. Grade I injuries represent a luminal irregularity with less than 25% stenosis of the parent vessel; these lesions are the most common and most benign. We reserve endovascular treatment of traumatic aneurysms for lesions demonstrating significant enlargement (linear distance between the expected location of the normal artery wall and the outer edge of the aneurysm lumen exceeds 15 mm) on follow-up imaging. Therefore, the use of stenting procedures in traumatically injured patients must be individualized and performed only after consultation with all surgical services involved with the care of the patient. Although heparin was long regarded as the "gold standard," antiplatelet medications are becoming more popular because of their equivalent efficacy in preventing ischemic complications and favorable side effect profile in comparison with heparin.

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The most common complication after endovascular permanent occlusion is hair loss in men versace order 1 mg finpecia fast delivery, of course, ischemic stroke. Postocclusion thromboembolism, coil migration, secondary aneurysm development, and perforator occlusion can also occur. In 1966, Nishioka39 reported a complication rate of 10% among 160 patients and cited ischemic infarction in only 2 of those patients. Advances in preoperative testing, patient selection, and endovascular occlusion techniques continue to improve endovascular results as does the coadministration of antiplatelet therapy in selected patients. Previous cerebrovascular disease can increase collateral flow through hypoxia and induced angiogenesis. Patients with moyamoya disease, arteriovenous shunting, congenital abnormalities, and even prior transient ischemic attacks show evidence of increased collateral circulation. The first test occlusion was performed by Matas27 and Carrol Allen in 1911, who advocated 20 to 30 minutes of carotid occlusion percutaneously or after surgical exposure, with the use of local anesthesia. This preliminary testing became known as the Matas test, but it was widely thought to lack sensitivity because it was difficult to effectively occlude the carotid artery fully for such a long time when it was attempted percutaneously. The modern endovascular version of this test has been extensively evaluated in the literature. Standard and associates30 showed that this testing reduced the rates of morbidity and mortality associated with permanent occlusion to less than 5%. With appropriate patient selection and preoperative testing, endovascular hunterian ligation can be a safe and effective treatment modality for complex intracranial vascular lesions. As the technology of flow-diverting devices improves, vessel sacrifice will be necessary in fewer patients. Hunterian proximal arterial occlusion for giant aneurysms of the carotid circulation. Testing the efficiency of the collateral circulation as a preliminary to the occlusion of the great surgical arteries. The transition from hunterian ligation to intracranial aneurysm clips: a historical perspective. Late morbidity and mortality of common carotid ligation for posterior communicating aneurysms. Ligation of basilar artery in treatment of an aneurysm at the basilar-artery bifurcation. Selective cerebral revascularization as an adjunct in the treatment of giant anterior circulation aneurysms. Treatment of aneurysms of the internal carotid artery by intravascular balloon occlusion: longterm follow-up of 58 patients.

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Mast cells in neovascularized human coronary plaques store and secrete basic fibroblast growth factor hair loss cure ayurveda buy finpecia 1 mg without a prescription, a potent angiogenic mediator. Co-accumulation of dendritic cells and natural killer T cells within rupture-prone regions in human atherosclerotic plaques. Colocalisation of intraplaque C reactive protein, complement, oxidised low density lipoprotein, and macrophages in stable and unstable angina and acute myocardial infarction. Association between complement factor H and proteoglycans in early human coronary atherosclerotic lesions: implications for local regulation of complement activation. Elevated levels of lipoprotein (a) in association with cerebrovascular saccular aneurysmal disease. Intra-aneurysmal hemodynamics in a large middle cerebral artery aneurysm with wall atherosclerosis. Genomewide linkage in a large Caucasian family maps a new locus for intracranial aneurysms to chromosome 13q. A balanced translocation truncates neurotrimin in a family with intracranial and thoracic aortic aneurysm. There are two important goals in the treatment of patients with intracranial aneurysms. In addition, the safety and efficacy of the treatment options and skill and experience of the practitioners need to be considered. The present chapter reviews the factors involved in decision making in the management of patients with cerebral aneurysms. Many patient-related factors will determine outcome irrespective of how the aneurysm is treated. Choosing the treatment modality that is safest and most efficient for each individual patient is an important therapeutic decision. This progress is reflected in the decreasing case fatality rate over recent years. By contrast, three quarters of the patients without postoperative neurological deterioration at 24 hours had a good outcome. This includes (1) patient age and comorbid conditions; (2) aneurysm morphology, lesion size, and attendant risk; (3) endovascular versus microsurgical accessibility/suitability, and long-term angiographic outcome; and (4) expected recovery duration and required longterm follow-up. Taken together, the natural history of the patient and the natural history of the particular aneurysm must be considered to determine the optimal approach to treatment. For example, the treatment of a small basilar bifurcation aneurysm in a 40-year-old will differ from that in an 80-year-old despite the similarity in the lesion.

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Lumbar spondylosis predisposes patients to intervertebral disc herniation hair loss cure ear order finpecia 1 mg visa, spondylolisthesis and spinal stenosis. Some patients may develop sclerotomal pain that radiates into the Disc herniation the nucleus pulposus in a degenerated disc may prolapse and push out from the weakened annulus, usually posterolaterally. This is a surgical emergency because neurological results are affected by the time to decompression. Whenever possible, the cauda equina syndrome should be recognized before incontinence becomes established. Greater degrees of spondylolisthesis occasionally cause sciatica, spinal stenosis or cauda equina syndrome. Symptoms are often bilateral with pain, weakness and sometimes paraesthesiae in the buttocks, thighs and legs. Forward flexion increases the canal diameter and may lead to the adoption of a simian stance. Physical examination is usually unremarkable, and severe neurological deficits are rarely seen. Most cases result from involvement of the spine by metastatic carcinoma (especially prostate, lung, breast, thyroid or kidney) or multiple myeloma. A majority of patients present with persistent and progressive pain that is often worse at night. A history of cancer, unexplained weight loss and older age are associated with a higher likelihood for cancer. Infection Vertebral osteomyelitis may be acute (usually pyogenic) or chronic (pyogenic, fungal or granulomatous). It usually results from hematogenous seeding, direct inoculation at the time of surgery or contiguous spread from adjacent soft tissue. Vertebral osteomyelitis may be complicated by an epidural or paravertebral abscess. Assessment A major focus of the evaluation is to identify the few patients with an underlying systemic disease (infection, neoplasm or spondyloarthritis) or significant neurological involvement (Box 4. It is essential to take a full history and perform a comprehensive physical examination. It is characterized by morning stiffness of greater than 30 minutes duration, improvement in back pain with exercise but not with rest, awakening because of back pain during the second half of the night, and Physical examination this rarely leads to a specific diagnosis. Structural scoliosis is secondary to structural changes of the vertebral column, generally the result of degenerative changes. Functional scoliosis is usually the result of paravertebral muscle spasm or leg length discrepancy.

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Percutaneous transfemoral embolization of an indirect carotid-cavernous fistula with cortical venous access to the cavernous sinus hair loss quick fix purchase finpecia visa. The superior ophthalmic vein approach for the treatment of carotid-cavernous fistulas: a novel technique using Onyx. Transorbital endovascular embolization of dural carotid-cavernous fistula: access to cavernous sinus through direct puncture: case examples and technical report. The evolution of endovascular treatment of carotid cavernous fistulas: a single-center experience. Stereotactic radiosurgery for the treatment of low-flow carotid-cavernous fistulae: results in a series of 25 cases. Although there are multiple classification schemes in the literature,22-24 the most commonly employed schemes are the Borden and Cognard classifications. These lesions are completely benign in nature, with no risk of intracranial hemorrhage or neurological deficit in their current state. They often are found incidentally or with benign symptoms, such as headache or pulsatile tinnitus. The Cognard classification also characterizes lesions based on the pattern of venous drainage, with added detail regarding the architecture of venous drainage in higher-grade lesions. Cognard type I fistulas have direct arterial-to-venous connection with entirely anterograde venous sinus drainage, and are akin to Borden type I fistulas. However, an increasing number of patients are now discovered asymptomatically owing to the increased use of advanced noninvasive cranial imaging. Low-grade lesions without venous reflux (Borden I or Cognard I) have an annual risk of hemorrhage of 0%, but do have a 1. A, Lateral subtracted angiogram of the left vertebral artery demonstrating a Borden type I dural arteriovenous fistula of the left transverse sinus. There is pial supply from the posterior temporal branch of the left posterior cerebral artery (black arrow) and dural supply from extracranial muscular (open arrows) and intradural posterior meningeal branches (white arrow) of the left vertebral artery. Transosseous collaterals of the extradural muscular branches are small in caliber (arrowhead), thus making these vessels less desirable targets for transarterial embolization. B, A radiopaque n-butyl-2-cyanoacrylate cast (arrowhead) in the left transverse sinus from previous left external carotid artery branch embolizations is better seen on the unsubtracted left vertebral artery angiogram. The catheter is situated in the proximal left transverse sinus, which has multifocal severe stenoses that functionally isolate the arterialized right transverse sinus pouch and force venous drainage retrograde. Contrast material refluxes into the superior sagittal sinus and supratentorial veins, as well as into the galenic system, occipital sinuses, and cerebellar veins. Often, superselective injections of feeding arteries are required to fully elucidate the anatomy and point of fistula. Occasionally, coils can be used to slow down highflow fistulas but are almost always combined with a liquid embolic agent for fistula cure. Accordingly, a multidisciplinary team of specialists, including open vascular neurosurgeons, endovascular specialists, and radiation oncologists, should manage all patients.

Alima, 42 years: Significant variability in the normal vasculature of the spinal cord can result in complex patterns that are difficult to interpret. The radiological diagnosis of cerebral venous angioma: cerebral angiography and computed tomography. The device consists of an electronic flow detection unit and a flow-sensing perivascular probe.

Umbrak, 52 years: Cerecyte coil trial: angiographic outcomes of a prospective randomized trial comparing endovascular coiling of cerebral aneurysms with either Cerecyte or bare platinum coils. Treatment of these aneurysms evolved to attempts to preserve the cerebral circulation and to avoid hunterian ligation. Patient-Specific Factors Smoking has been associated with a lower rate of obliteration after treatment in a large study of 774 patients that included 444 (57.

Kerth, 57 years: Sentinel headaches in aneurysmal subarachnoid haemorrhage: what is the true incidence Methotrexate is an antimetabolite with antiinflammatory and immunomodulatory properties. It is also a good treatment choice for patients whose age or comorbidities make the risk of general anesthesia unacceptable.

Dan, 36 years: The patient underwent vertebral-carotid transposition with resolution of his symptoms. Contribution of endovascular therapy to the management of poor-grade aneurysmal subarachnoid hemorrhage: clinical and angiographic outcomes. Septic arthritis usually occurs in large joints, generally involving a single joint.

Randall, 32 years: The drill is used to carry out the craniotomy, and the keyhole region is drilled down to the internal sphenoid ridge. Warfarin is the most frequently encountered systemic anticoagulant and is commonly used for thromboembolism prevention in patients with conditions such as mechanical heart valves and atrial fibrillation. The main trunk of the anterior spinal artery descends along the entire length of the cord in the anterior median fissure, a midline cleft that divides the spinal cord into left and right hemicords.

Candela, 28 years: Cerebellopontomandibular vascular malformation: a rare type of cerebrofacial arteriovenous metameric syndrome. Surgical management of cervical radiculopathy caused by redundant vertebral artery loop. Three-dimensional dynamic magnetic resonance angiography for the evaluation of radiosurgically treated cerebral arteriovenous malformations.

Hanson, 48 years: Statistical analysis of factors affecting the outcome of patients with ruptured distal anterior cerebral artery aneurysms. In cases in which stenting is not possible, further cranial exposure of the carotid complex can be achieved. Hunt Batjer the open, surgical treatment of basilar apex aneurysms has largely been replaced by endovascular treatment.

Miguel, 26 years: In their summation of the literature, 84% of patients had a good outcome and 12% died. It was associated with chronic paraparesis that was progressing in a stuttering, subacute manner. Delayed neurological deterioration following resection of arteriovenous malformations of the brain.

Sigmor, 45 years: On the other hand, already mentioned in this chapter is a small subgroup of patients who suffer a delayed and often global decline in neurological status for which no underlying cause can be identified, including cerebral vasospasm. In particular, we recommend aggressive control of hypertension, prompt institution of calcium channel blockers. Trevo System: single-center experience with a novel mechanical thrombectomy device.

Vasco, 39 years: The selection of one treatment over the other requires a careful consideration of both patientand aneurysm-specific factors. Vascular injury and compression owing to trauma or mass lesions cause local endothelial damage and altered hemodynamics. Volume staging and hypofractionation can therefore successfully downgrade these lesions, making them more amenable to microsurgical resection.

Olivier, 43 years: Asymptomatic radiation-induced telangiectasia in children after cranial irradiation: frequency, latency, and dose relation. Onyx did not penetrate the right sigmoid sinus because of distal occlusion of the right transverse sinus, which prevented transvenous access in this case. Humans, and some primates, lack uricase, which in other mammals oxidizes urate to allantoin, which is readily soluble.

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